Agave victoriae-reginae originates from the Sierra Madre Oriental Mountains in the state of Coahuila, and south of Nuevo Leon, in northeastern Mexico. It is found in lower elevation slopes and near vertical cliffs of desert canyons, in calcareous soils. While endangered in its natural habitat, the species is abundant in cultivation.
A. ferdinandi-regis is officially synonymous to A. victoriae-reginae, despite some sources considering the former to possess a more open and larger rosette with fewer, more narrow leaves; less bud imprinting; and darker edges than the latter.