This species will grow more slowly than most barrel cacti, and will form aggregations in mature specimens.
Water regularly during the growing season, and suspend irrigation in winter. Allow soil to fully dry out in between waterings, and do not allow to stand in water. Plant in average, well-drained, gritty soil, from mildly acidic to mildly alkaline (6.1 – 7.8). Full sun is required for this species to thrive - however, provide partial shade if the site is very hot, in order to prevent burning or discoloration. The cold tolerance of this species is 25°F, USDA hardiness zones 9b to 11.
F. pilosus can be propagated through offsets or seeds collected from over-ripe fruits.